https://www.biostars.org/local/search/page/?q=cytoscape+GeneMANIA

 



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  GDNF (Glial cell line-derived neurotrophic factor) is a member of the transforming growth factor-beta superfamily, GDNF was was first recognized from glial cells for the ability to protect dopaminergic neurons in the midbrain (Engele et al., 1991; Lin et al., 1993), GDNF is also for ENS (Enteric Nervous System). At current it is known that overexpression, or abnormal expression of GDNF cause brain tumor, hirschsprung disease and especially related to neurocognitive functions (schizophrenia) and tendency of habit, for example GDNF has been regarded as potential common addiction-related gene (for instance, drug use, alcohol abuse, etc.). This is probably because GDNF is expressed in brain and other neuron cells. When analyzing the GDNF interaction with other genes at https://genemania.org/ , for instance with PTGS2 (or COX-2, an enzyme for prostaglandins): https://genemania.org/search/homo-sapiens/GDNF/PTGS2, then I got a quick idea, just wonder if these gene network could be conve...
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